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Browsing by Author "Wellington, Kevin W"

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Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus

Author: Sakong, BM ; Adenubi, OT ; Pauw, E ; Eloff, JN ; Fouché, Gerda ; Leboho, Tlabo ; Wellington, Kevin W Date: 2016 The nematode, Haemonchus contortus, is responsible for major economic losses in the livestock industry. The management of parasites such as H. contortus has been through the use of synthetic parasiticides. This has resulted in the presence ... Read more
Convenient synthesis of N,N'-dibenzyl-2,4-diaminopyrimidine-2'-deoxyribonucleoside and 1-methyl-2'-deoxypseudoisocytidine

Author: Wellington, Kevin W ; Ooi, HC ; Benner, SA Date: Apr 2009 The syntheses of N,N'-dibenzyl-2,4-diaminopyrimidine-2'-deoxyribonucleoside and 1-methyl-2'- deoxypseudoisocytidine via Heck coupling are described. A survey of the attempts to use the Heck coupling to synthesize N,N'-dibenzyl-2,4-diaminopy ... Read more
Designer ligands. Part 14. Novel Mn(lI), Ni(II) and Zn(II) complexes of benzamide- and biphenyl-derived ligands

Author: Wellington, Kevin W ; Kaye, PT ; Watkins, GM Date: Jan 2009 Manganese (II), nickel (II) and zinc (II) complexes have been prepared using various benzamideand biphenyl-derived ligands; their structures have been investigated using infrared spectroscopy and it is apparent that, depending on the ligand, ... Read more
Designer ligands. Part 15. Synthesis and characterisation of novel Mn(lI), Ni(II) and Zn(II) complexes of 1,10-phenanthroline-derived ligands

Author: Wellington, Kevin W ; Kaye, PT ; Watkins, GM Date: 2009 Series of manganese(II), nickel(II) and zinc(II) complexes have been prepared using 1,10-phenanthroline-derived ligands, and their coordination geometries have been assigned using infrared data. It is apparent that, depending on the ligand, ... Read more
Diamination by n-coupling using a commercial laccase

Author: Wellington, Kevin W ; Steenkamp, P ; Brady, D Date: Feb 2010 Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalyzed by a immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions ... Read more
Evaluation of South African plants with acaricide activity against ticks

Author: Fouché, Gerda ; Eloff, JN ; Wellington, Kevin W Date: 2017 Acaricides are commonly used to control ticks but are toxic, harmful to the environment and too expensive to resource-limited farmers. Traditionally, many communities in South Africa rely on a wide range of indigenous practices to keep their ... Read more
Further studies on South African plants: Acaricidal activity of organic plant extracts against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)

Author: Wellington, Kevin W ; Leboho, T ; Sakong, BM ; Adenubi, OT ; Eloff, JN ; Fouché, Gerda Date: Jan 2017 The goal of our research is to develop a lower cost eco-friendly tick control method because acaricides that are commonly used to control ticks are often toxic, harmful to the environment or too expensive for resource-limited farmers. Acetone ... Read more
InCl3: A versatile catalyst for synthesizing a broad spectrum of heterocycles

Author: Mahato, SK ; Acharya, C ; Wellington, Kevin W ; Bhattacharjee, P ; Jaisankar, P Date: Feb 2020 This review deals with the recent applications of the indium trichloride (InCl3) catalyst in the synthesis of a broad spectrum of heterocyclic compounds. Over the years, a number of reviews on the applications of InCl3-catalyzed organic ... Read more
InCl3: A versatile catalyst for synthesizing a broad spectrum of heterocycles

Author: Mahato, SK ; Acharya, C ; Wellington, Kevin W ; Bhattacharjee, P ; Jaisankar, P Date: Feb 2020 This review deals with the recent applications of the indium trichloride (InCl(sub3)) catalyst in the synthesis of a broad spectrum of heterocyclic compounds. Over the years, a number of reviews on the applications of InCl(sub3)-catalyzed ... Read more
Investigation of the acaricidal activity of the acetone and ethanol extracts of 12 South African plants against the adult ticks of Rhipicephalus turanicus

Author: Fouché, Gerda ; Sakong, BM ; Adenubi, OT ; Dzoyem, JP ; Naidoo, V ; Leboho, Tlabo ; Wellington, Kevin W ; Eloff, JN Date: Nov 2017 The acaricidal activity of acetone and ethanol extracts of 12 plant species was evaluated using the contact method on Rhipicephalus turanicus (Acari: Ixodidae) ticks at an initial concentration of 20% (200 mg/mL). Eight of the 12 plants had ... Read more
Investigation of the antibacterial and antifungal activity of thiolated naphthoquinones

Author: Wellington, Kevin W ; Nyoka, NBP ; McGaw, LJ Date: Jan 2019 The WHO has stated that antibiotic resistance is escalating to perilously high levels globally and that traditional therapies of antimicrobial drugs are futile against infections caused by resistant microorganisms. Novel antimicrobial drugs ... Read more
A Laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity

Author: Wellington, Kevin W ; Kolesnikova, NI Date: May 2012 Nuclear monoamination of a 1,4-naphthohydroquinone with primary aromatic amines was catalysed by the commercial laccase, Novozym 51003, from Novozymes to afford aminonaphthoquinones. The synthesis was accomplished by reacting a mixture of the ... Read more
A laccase-catalysed synthesis of triaminated cyclohexa-2,4-dienones from catechol

Author: Wellington, Kevin W ; Govindjee, Varsha P ; Steenkamp, Paul Date: Dec 2018 A commercial laccase, Suberase from Novozymes, catalyses the synthesis of triaminated cyclohexa-2,4-dienones and a methylbenzene-1,2-diol derivative. The primary amine (analine) and the catechol was reacted under mild conditions (40C) in a ... Read more
Laccase-catalyzed C-S and C-C coupling for a one-pot synthesis of 1,4-naphthoquinone sulfides and 1,4-naphthoquinone sulfide dimers

Author: Wellington, Kevin W ; Gordon, GER ; Ndlovu, LA ; Steenkamp, P Date: Jun 2013 Oxidative C-S and C-C bond formation with aryl and alkyl thiols was catalyzed under mild conditions in a reaction vessel open to air at pH 4.5 in the presence of a commercial laccase (Novozym 51003 or Suberase) and a cosolvent (DMF) to afford ... Read more
A one-pot laccase-catalysed synthesis of 5,6-dihydroxylated benzo[b]furans and catechol derivatives, and their anticancer activity

Author: Wellington, Kevin W ; Qwebani-Ogunleye, T ; Kolesnikova, NI ; Brady, D ; De Koning, CB Date: Apr 2013 A commercial laccase, Suberase® from Novozymes, was used to catalyse the synthesis of 5,6-dihydroxylated benzo[b]furans and catechol derivatives. The yields were, in some cases, similar to or better than that obtained by other enzymatic, ... Read more
A one-pot laccase-catalysed synthesis of coumestan derivatives and their anticancer activity

Author: Qwebani-Ogunleye, Tozama ; Kolesnikova, Natalia I ; Steenkamp, Paul A ; De Koning, CB ; Brady, D ; Wellington, Kevin W Date: Dec 2016 Suberase®, a commercial laccase from Novozymes, was used to catalyse the synthesis of coumestans. The yields, in some cases, were similar to or better than that obtained by other enzymatic, chemical or electrochemical syntheses. The compounds ... Read more
Understanding cancer and the anticancer activities of naphthoquinones – a review

Author: Wellington, Kevin W Date: Feb 2015 The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million cases over the next two decades. Radiotherapy and surgical approaches have been ... Read more c b

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