Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalyzed by a immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35oC in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diaminated pbenzoquinone. These compounds may have potential antiallergic, antibiotic, anticancer, antifungal, antiviral and 5-lipoxygenase inhibiting activity.
Reference:
Wellington, KW, Steenkamp, P, and Brady, D. 2010. Diamination by n-coupling using a commercial laccase. Bioorganic and Medicinal Chemistry, Vol. 18, pp 1406–1414
Wellington, K. W., Steenkamp, P., & Brady, D. (2010). Diamination by n-coupling using a commercial laccase. http://hdl.handle.net/10204/4212
Wellington, Kevin W, P Steenkamp, and D Brady "Diamination by n-coupling using a commercial laccase." (2010) http://hdl.handle.net/10204/4212
Wellington KW, Steenkamp P, Brady D. Diamination by n-coupling using a commercial laccase. 2010; http://hdl.handle.net/10204/4212.
Copyright: 2010 Elsevier. This is the author's accepted manuscript, the definitive version is published in the Bioorganic and Medicinal Chemistry Journal, Vol. 18(4), pp 1406–1414
