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Browsing by Author "Mufhandu, Hazel T"

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Development of aptamer based HIV-1 entry inhibitor prophylactic drugs

Author: London, G ; Mufhandu, Hazel T ; Sok, D ; Morris, L ; Burton, DR ; Mayosi, B ; Khati, M Date: Aug 2013 AIDS remains a major public health problem globally, especially in Southern Africa where over 6.4 million people are infected by the most prevalent HIV-1 subtype C. To help stop the spread of HIV-1 subtype C, we isolated 2ʹ-F-RNA aptamers ... Read more
HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer

Author: Mufhandu, Hazel T ; Alexandre, Kabamba B ; Gray, ES ; Morris, L ; Khati, M Date: Sep 2012 Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for ... Read more
The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

Author: Alexandre, Kabamba B ; Gray, ES ; Mufhandu, Hazel T ; McMahon, JB ; Chakauya, E ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Feb 2012 It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer to CD4(+) cells. The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) ... Read more
Neutralization of several adult and paediatric HIV-1 subtype C isolates using a shortened synthetic derivative of gp120 binding aptamer called UCLA1.

Author: Mufhandu, Hazel T ; Madiga, M ; Gray, E ; Rotherham, L ; Khoza, T ; Morris, L ; Khati, M Date: Jul 2009 This paper present a chemically synthesised derivative of the B40 parental aptamer, called UCLA1 (Cohen et al., 2008), was used for neutralization of endemic subtype C clinical isolates of HIV-1 from adult and paediatric patients and subtype ... Read more
Progress and perspectives on HIV-1 microbicide development

Author: Alexandre, Kabamba B ; Mufhandu, Hazel T ; London, GM ; Chakauya, E ; Khati, M Date: Oct 2016 The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender ... Read more
UCLA1 aptamer inhibition of human immunodeficiency virus type 1 subtype C primary isolates in macrophages and selection of resistance

Author: Mufhandu, Hazel T ; Alexandre, Kabamba B ; Gray, ES ; Morris, L ; Khati, M Date: Sep 2016 We have previously shown that the aptamer, UCLA1, is able to inhibit HIV-1 replication in peripheral blood mononuclear cells (PBMCs) by binding to residues in gp120. In this study we examined whether UCLA1 was effective against HIV-1 subtype ... Read more
UCLA1, a synthetic derivative of a gp120 RNA aptamer, inhibits entry of human immunodeficiency virus type 1 subtype C

Author: Mufhandu, Hazel T ; Gray, ES ; Madiga, MC ; Tumba, N ; Alexandre, Kabamba B ; Khoza, T ; Wibmer, CK ; Moore, PL ; Morris, L ; Khati, M Date: May 2012 Entry of human immunodeficiency virus type 1 (HIV-1) into cells is mediated by the virion surface envelope (Env) glycoproteins, making it a desirable target for antiretroviral entry inhibitors. We previously isolated a family of gp120 binding ... Read more

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Browsing by Author "Mufhandu, Hazel T"

Browsing by Author "Mufhandu, Hazel T"

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