Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for neutralization of subtype C primary isolates in PBMC and monocyte-derived macrophages (MDM). We also assessed the ability of subtype C to develop resistance to UCLA1 inhibition by propagating the isolates in increasing concentrations of the aptamer.
Reference:
Mufhandu, HT, Alexandre, KB, Gray, ES, Morris, L and Khati, M. 2012. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. Retrovirology, vol. 9 (supplement 2), p. 215
Mufhandu, H. T., Alexandre, K. B., Gray, E., Morris, L., & Khati, M. (2012). HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. http://hdl.handle.net/10204/6312
Mufhandu, Hazel T, Kabamba B Alexandre, ES Gray, L Morris, and M Khati "HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer." (2012) http://hdl.handle.net/10204/6312
Mufhandu HT, Alexandre KB, Gray E, Morris L, Khati M. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. 2012; http://hdl.handle.net/10204/6312.
Copyright: 2012 Mufhandu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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