Seventeen silyl- and trityl-modified (5'-O- and 3',5'-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentration of 100 µM against a small panel of tumor cell lines (HL-60, K-562, Jurkat, Caco-2 and HT-29). The entire set was also tested at varying concentrations against two human glioma lines (U373 and Hs683) to obtain GI(sub50) values, with the best results being values of 25 µM.
Reference:
Panayides, J-L. Mathieu, V. Banuls, L.M.Y. Apostolellis, H. Dahan-Farkas, N. Davids, H. Harmse, L. Rey, M.E.C. Green, I.R. Pelly, S.C. Kiss, R. Kornienko, A. and Van Otterlo, W.A.L. 2016. Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. Bioorganic & Medicinal Chemistry, 24(16), 2716-2724
Panayides, J., Mathieu, V., Banuls, L., Apostolellis, H., Dahan-Farkas, N., Davids, H., ... Van Otterlo, W. (2016). Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. http://hdl.handle.net/10204/8768
Panayides, Jenny-Lee, V Mathieu, LMY Banuls, H Apostolellis, N Dahan-Farkas, H Davids, L Harmse, et al "Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides." (2016) http://hdl.handle.net/10204/8768
Panayides J, Mathieu V, Banuls L, Apostolellis H, Dahan-Farkas N, Davids H, et al. Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. 2016; http://hdl.handle.net/10204/8768.
Copyright: 2015 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Bioorganic & Medicinal Chemistry, 24(16), 2716-2724
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