There is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells. We hypothesized that curdlan (immune stimulating polymer) could be conjugated to PLGA and nanoparticles from this copolymer would possess immunostimulatory activity, be non-cytotoxic and function as an effective sustained drug release system.
Reference:
Tukulula, M, Hayeshi, R, Fonteh, P, Meyer, D, Ndamase, A, Madziva, M.T, Khumalo, V, Lubuschagne, P, Naicker, B, Swai, H and Dube, A. 2015. Curdlan-conjugated PLGA nanoparticles possess macrophage stimulant activity and drug delivery capabilities. Pharmaceutical Research, vol. 32(8), pp 2713-2726
Tukulula, M., Hayeshi, R., Fonteh, P., Meyer, D., Ndamase, A., Madziva, M., ... Dube, A. (2015). Curdlan-conjugated PLGA nanoparticles possess macrophage stimulant activity and drug delivery capabilities. http://hdl.handle.net/10204/8026
Tukulula, M, R Hayeshi, P Fonteh, D Meyer, A Ndamase, MT Madziva, V Khumalo, et al "Curdlan-conjugated PLGA nanoparticles possess macrophage stimulant activity and drug delivery capabilities." (2015) http://hdl.handle.net/10204/8026
Tukulula M, Hayeshi R, Fonteh P, Meyer D, Ndamase A, Madziva M, et al. Curdlan-conjugated PLGA nanoparticles possess macrophage stimulant activity and drug delivery capabilities. 2015; http://hdl.handle.net/10204/8026.
Copyright: 2015 Springer. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Pharmaceutical Research, vol. 32(8), pp 2713-2726
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