In South Africa, Salvia repens is used traditionally to treat sores, stomach ache and diarrhoea. The high performance liquid chromatography (HPLC)-based activity profiling of S. repens whole plant extract showed an active abietane diterpene, identified as 12-methoxycarnosic acid (1) which showed antiprotozoal activity against axenically grown Leishmania donovani amastigotes with an IC(sub50) of 0.75 µM with marginal cytotoxicity against the L6-cells (IC(sub50), 17.3 µM).
Reference:
Mokoka, T.A, Peter, X.K, Fouche, G, Moodley, N, Adams, M, Hamburger, M, Kaiser, M, Brun, R, Maharaj, V and Koorbanally, N. 2014. Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae). South African Journal of Botany, vol. 90, pp 93-95
Mokoka, T., Peter, X. K., Fouché, G., Moodley, N., Adams, M., Hamburger, M., ... Koorbanally, N. A. (2014). Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae). http://hdl.handle.net/10204/7354
Mokoka, TA, Xolani K Peter, Gerda Fouché, N Moodley, M Adams, M Hamburger, M Kaiser, R Brun, V Maharaj, and Nicoli A Koorbanally "Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)." (2014) http://hdl.handle.net/10204/7354
Mokoka T, Peter XK, Fouché G, Moodley N, Adams M, Hamburger M, et al. Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae). 2014; http://hdl.handle.net/10204/7354.
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