dc.contributor.author |
Mokoka, TA
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dc.contributor.author |
Peter, Xolani K
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dc.contributor.author |
Zimmermann, S
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dc.contributor.author |
Hata, Y
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dc.contributor.author |
Adams, M
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dc.contributor.author |
Kaiser, M
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dc.contributor.author |
Moodley, N
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dc.contributor.author |
Maharaj, V
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dc.contributor.author |
Koorbanally, Nicoli A
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dc.contributor.author |
Hamburger, M
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dc.contributor.author |
Brun, B
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dc.contributor.author |
Fouché, Gerda
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dc.date.accessioned |
2013-09-30T08:05:09Z |
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dc.date.available |
2013-09-30T08:05:09Z |
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dc.date.issued |
2013-08 |
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dc.identifier.citation |
Mokoka, T.A, Peter, X.K, Zimmermann, S, Hata, Y, Adams, M, Kaiser, M, Moodley, N, Maharaj, V, Koorbanally, N.A, Hamburger, M, Brun, R and Fouche, G. 2013. Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. Planta Medica, vol. 70, pp 1-5 |
en_US |
dc.identifier.issn |
0032-0943 |
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dc.identifier.uri |
https://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1350691
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dc.identifier.uri |
http://hdl.handle.net/10204/6967
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dc.description |
Copyright: 2013 Georg Thieme Verlag. This is an ABSTRACT ONLY. The definitive version is published in Planta Medica, vol. 70, pp 1-5 |
en_US |
dc.description.abstract |
Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts which inhibited the growth of one or more parasites with more than 95 % at 10 µg/mL, the IC(sub)50 values against all four protozoal parasites and cytotoxic IC(sub)50 values against L6 myoblasts were determined. Amongst the most notable results are the activities of Psoralea pinnata (IC(sub)50 of 0.15 µg/mL), Schkuhria pinnata (2.04 µg/mL), and Vernonia mespilifolia (1.01 µg/mL) against Trypansoma brucei rhodesiense. HPLC-based activity profiling was used to identify the active constituents in the extracts, and the germacranolide sesquiterpene lactones schkuhrin I and II from S. pinnata, and cynaropicrin from V. mespilifolia were identified, with IC(sub)50 values of 0.9, 1.5, and 0.23 µM, respectively. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Georg Thieme Verlag |
en_US |
dc.relation.ispartofseries |
Workflow;11468 |
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dc.subject |
Plant extract library |
en_US |
dc.subject |
Screening |
en_US |
dc.subject |
Antiprotozoal activity |
en_US |
dc.subject |
Sesquiterpene lactones |
en_US |
dc.subject |
Trypanosoma cruzi |
en_US |
dc.subject |
Leishmania donovani |
en_US |
dc.subject |
Plasmodium falciparum |
en_US |
dc.subject |
Psoralea pinnata (Fabaceae) |
en_US |
dc.subject |
Schkuhria pinnata (Asteraceae) |
en_US |
dc.subject |
Vernonia mespilifolia (Asteraceae) |
en_US |
dc.title |
Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Mokoka, T., Peter, X. K., Zimmermann, S., Hata, Y., Adams, M., Kaiser, M., ... Fouché, G. (2013). Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. http://hdl.handle.net/10204/6967 |
en_ZA |
dc.identifier.chicagocitation |
Mokoka, TA, Xolani K Peter, S Zimmermann, Y Hata, M Adams, M Kaiser, N Moodley, et al "Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II." (2013) http://hdl.handle.net/10204/6967 |
en_ZA |
dc.identifier.vancouvercitation |
Mokoka T, Peter XK, Zimmermann S, Hata Y, Adams M, Kaiser M, et al. Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. 2013; http://hdl.handle.net/10204/6967. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Mokoka, TA
AU - Peter, Xolani K
AU - Zimmermann, S
AU - Hata, Y
AU - Adams, M
AU - Kaiser, M
AU - Moodley, N
AU - Maharaj, V
AU - Koorbanally, Nicoli A
AU - Hamburger, M
AU - Brun, B
AU - Fouché, Gerda
AB - Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts which inhibited the growth of one or more parasites with more than 95 % at 10 µg/mL, the IC(sub)50 values against all four protozoal parasites and cytotoxic IC(sub)50 values against L6 myoblasts were determined. Amongst the most notable results are the activities of Psoralea pinnata (IC(sub)50 of 0.15 µg/mL), Schkuhria pinnata (2.04 µg/mL), and Vernonia mespilifolia (1.01 µg/mL) against Trypansoma brucei rhodesiense. HPLC-based activity profiling was used to identify the active constituents in the extracts, and the germacranolide sesquiterpene lactones schkuhrin I and II from S. pinnata, and cynaropicrin from V. mespilifolia were identified, with IC(sub)50 values of 0.9, 1.5, and 0.23 µM, respectively.
DA - 2013-08
DB - ResearchSpace
DP - CSIR
KW - Plant extract library
KW - Screening
KW - Antiprotozoal activity
KW - Sesquiterpene lactones
KW - Trypanosoma cruzi
KW - Leishmania donovani
KW - Plasmodium falciparum
KW - Psoralea pinnata (Fabaceae)
KW - Schkuhria pinnata (Asteraceae)
KW - Vernonia mespilifolia (Asteraceae)
LK - https://researchspace.csir.co.za
PY - 2013
SM - 0032-0943
T1 - Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II
TI - Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II
UR - http://hdl.handle.net/10204/6967
ER -
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en_ZA |