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Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

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dc.contributor.author Becker, JVW
dc.contributor.author Mtwisha, L
dc.contributor.author Crampton, BG
dc.contributor.author Stoychev, Stoyan H
dc.contributor.author Van Brummelen, AC
dc.contributor.author Reeksting, S
dc.contributor.author Louw, AI
dc.contributor.author Birkholtz, LM
dc.contributor.author Mancama, Dalubuhle T
dc.date.accessioned 2010-11-11T10:21:12Z
dc.date.available 2010-11-11T10:21:12Z
dc.date.issued 2010-01
dc.identifier.citation Becker, JVW, Mtwisha, L, Crampton, BG et al. 2010. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. BMC Genomics, Vol. 11(235), pp 1-16 en
dc.identifier.issn 1471-2164
dc.identifier.uri http://hdl.handle.net/10204/4549
dc.description Copyright: 2010 Becker et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited en
dc.description.abstract This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine depletion in this parasite. Moreover, they confirm the role of transcriptional regulation in P. falciparum, particularly in this pathway. The findings promote this essential pathway as a target for antimalarial chemotherapeutic intervention strategies en
dc.language.iso en en
dc.publisher Authors en
dc.relation.ispartofseries Journal Article en
dc.subject Plasmodium falciparum en
dc.subject Plasmodium falciparum spermidine synthase en
dc.subject PfSpdSyn en
dc.subject Antimalarial drug resistance en
dc.subject Malaria en
dc.subject Human malaria en
dc.subject Genomics en
dc.title Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels en
dc.type Article en
dc.identifier.apacitation Becker, J., Mtwisha, L., Crampton, B., Stoychev, S. H., Van Brummelen, A., Reeksting, S., ... Mancama, D. T. (2010). Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. http://hdl.handle.net/10204/4549 en_ZA
dc.identifier.chicagocitation Becker, JVW, L Mtwisha, BG Crampton, Stoyan H Stoychev, AC Van Brummelen, S Reeksting, AI Louw, LM Birkholtz, and Dalubuhle T Mancama "Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels." (2010) http://hdl.handle.net/10204/4549 en_ZA
dc.identifier.vancouvercitation Becker J, Mtwisha L, Crampton B, Stoychev SH, Van Brummelen A, Reeksting S, et al. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. 2010; http://hdl.handle.net/10204/4549. en_ZA
dc.identifier.ris TY - Article AU - Becker, JVW AU - Mtwisha, L AU - Crampton, BG AU - Stoychev, Stoyan H AU - Van Brummelen, AC AU - Reeksting, S AU - Louw, AI AU - Birkholtz, LM AU - Mancama, Dalubuhle T AB - This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine depletion in this parasite. Moreover, they confirm the role of transcriptional regulation in P. falciparum, particularly in this pathway. The findings promote this essential pathway as a target for antimalarial chemotherapeutic intervention strategies DA - 2010-01 DB - ResearchSpace DP - CSIR KW - Plasmodium falciparum KW - Plasmodium falciparum spermidine synthase KW - PfSpdSyn KW - Antimalarial drug resistance KW - Malaria KW - Human malaria KW - Genomics LK - https://researchspace.csir.co.za PY - 2010 SM - 1471-2164 T1 - Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels TI - Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels UR - http://hdl.handle.net/10204/4549 ER - en_ZA


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