A compound possessing anti-HIV activity similar to that of FDA-approved nevirapine was developed. It acts as a non-nucleoside reverse transcriptase inhibitor, the compound shows good cell permeability, and a quantitative structure activity relationship (QSAR) was developed for the compound series.
Reference:
Bode, M, Gledhill, I, Gravestock, D, Hoppe, H et al. 2010. Compounds acting against HIV: Imidazo[1,2-a]pyridines as non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTI presentation CSIR conference 2010, pp 16
Bode, M., Gledhill, I. M., Gravestock, D., Hoppe, H., Khan, T., Moleele, S., ... Van der Westhuyzen, C. W. (2010). Compounds acting against HIV: Imidazo[1,2-a]pyridines as non-nucleoside reverse transcriptase inhibitors (NNRTIs). CSIR. http://hdl.handle.net/10204/4369
Bode, M, Irvy MA Gledhill, D Gravestock, H Hoppe, T Khan, S Moleele, L Nkabinde, S Pelly, and Christiaan W Van der Westhuyzen. "Compounds acting against HIV: Imidazo[1,2-a]pyridines as non-nucleoside reverse transcriptase inhibitors (NNRTIs)." (2010): http://hdl.handle.net/10204/4369
Bode M, Gledhill IM, Gravestock D, Hoppe H, Khan T, Moleele S, et al, Compounds acting against HIV: Imidazo[1,2-a]pyridines as non-nucleoside reverse transcriptase inhibitors (NNRTIs); CSIR; 2010. http://hdl.handle.net/10204/4369 .
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