The research conducted by the Bioprospecting group to identify TB drug leads using the accelerated approach will be outlined. The Bioprospecting platform in collaboration with the South African National Botanical Institute (SANBI) has established a dedicated and comprehensive plant electronic database of a total of 566 plants that are reportedly used for the treatment of tuberculosis. The extracts of these plants are part of the CSIR database of extracts. TB drug lead research is ongoing, and active ingredients will be subjected to computational chemistry to identify potential sites for structural modification to improve bioavailability and decrease cytotoxicity
Reference:
Naidoo, D, Maharaj, VJ, Moodley, N et al. Accelerated approach of discovering plant derived drug leads for treatment of TB. Oral Presentation - IPUF conference, pp 1
Naidoo, D., Maharaj, V., Moodley, N., Sewnarain, P., & Ndlebe, V. (2010). Accelerated approach of discovering plant derived drug leads for treatment of TB. http://hdl.handle.net/10204/4124
Naidoo, Dashnie, VJ Maharaj, N Moodley, P Sewnarain, and VJ Ndlebe. "Accelerated approach of discovering plant derived drug leads for treatment of TB." (2010): http://hdl.handle.net/10204/4124
Naidoo D, Maharaj V, Moodley N, Sewnarain P, Ndlebe V, Accelerated approach of discovering plant derived drug leads for treatment of TB; 2010. http://hdl.handle.net/10204/4124 .
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