ResearchSpace

Biocatalytic preparation of 5-methyluridine (5-MU)

Show simple item record

dc.contributor.author Gordon, GER
dc.contributor.author Visser, Daniel F
dc.contributor.author Bode, ML
dc.contributor.author Brady, D
dc.date.accessioned 2008-12-09T13:29:53Z
dc.date.available 2008-12-09T13:29:53Z
dc.date.issued 2008-11
dc.identifier.citation Gordon, GER, Visser, DF, Bode, ML and Brady, D. 2008. Biocatalytic preparation of 5-methyluridine (5-MU). Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008, pp 1 en
dc.identifier.uri http://hdl.handle.net/10204/2687
dc.description Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008 en
dc.description.abstract The potential of chemo-enzymatic methods to produce active pharmaceutical ingredients (APIs) such as stavudine (d4T) and zidovudine (AZT) has been demostrated during this investigation. The effect of increasing reactor productivity to commercially viable levels, albeit as low substrate solubilities, was also demonstrated. The process also demonstrated the isolation of 5-methyluridine (5-MU) from the biocatalytic reaction and integration into the subsequent chemical steps to produce B-thymidime, a key intermediate in the preparation of antiretrovirals. The current paper discusses how the above challenges were successfully overcome and implemented at 20 L scale. en
dc.language.iso en en
dc.publisher CSIR en
dc.subject 5-methyluridine (5-MU) en
dc.subject Biocatalytic preparation en
dc.subject Biocatalysis en
dc.title Biocatalytic preparation of 5-methyluridine (5-MU) en
dc.type Conference Presentation en
dc.identifier.apacitation Gordon, G., Visser, D. F., Bode, M., & Brady, D. (2008). Biocatalytic preparation of 5-methyluridine (5-MU). CSIR. http://hdl.handle.net/10204/2687 en_ZA
dc.identifier.chicagocitation Gordon, GER, Daniel F Visser, ML Bode, and D Brady. "Biocatalytic preparation of 5-methyluridine (5-MU)." (2008): http://hdl.handle.net/10204/2687 en_ZA
dc.identifier.vancouvercitation Gordon G, Visser DF, Bode M, Brady D, Biocatalytic preparation of 5-methyluridine (5-MU); CSIR; 2008. http://hdl.handle.net/10204/2687 . en_ZA
dc.identifier.ris TY - Conference Presentation AU - Gordon, GER AU - Visser, Daniel F AU - Bode, ML AU - Brady, D AB - The potential of chemo-enzymatic methods to produce active pharmaceutical ingredients (APIs) such as stavudine (d4T) and zidovudine (AZT) has been demostrated during this investigation. The effect of increasing reactor productivity to commercially viable levels, albeit as low substrate solubilities, was also demonstrated. The process also demonstrated the isolation of 5-methyluridine (5-MU) from the biocatalytic reaction and integration into the subsequent chemical steps to produce B-thymidime, a key intermediate in the preparation of antiretrovirals. The current paper discusses how the above challenges were successfully overcome and implemented at 20 L scale. DA - 2008-11 DB - ResearchSpace DP - CSIR KW - 5-methyluridine (5-MU) KW - Biocatalytic preparation KW - Biocatalysis LK - https://researchspace.csir.co.za PY - 2008 T1 - Biocatalytic preparation of 5-methyluridine (5-MU) TI - Biocatalytic preparation of 5-methyluridine (5-MU) UR - http://hdl.handle.net/10204/2687 ER - en_ZA


Files in this item

Thumbnail
Name: Gordon_P_2008.pdf
Size: 503.4Kb
Format: PDF
View/Open

This item appears in the following Collection(s)

Show simple item record