Polyurethane (PU) may be suitable for various implant applications; however, it lacks bioactivity. Bioactivity allows for direct tissue attachment at the bio- interface, enabling implant fixation while preventing fibrous encapsulation. To impart bioactivity, PU was coated with a layer of hydroxyapatite (HA) by a solvent- compression method. Bioactivity of the HA- coated PU substrates was demonstrated by incubation in simulated body fluid (SBF) for up to nine days. Using crystal violet DNA staining and MTT (3- [4,5 dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide) assay for determining the cell number and cell metabolic activity respectively, cytocompatibility of the HA-coated PU substrates was demonstrated towards a number of cell lines. The HA-coated PU substrates prepared in this study could find application where non- resorbable biomaterials are required, including cartilage replacement, maxillofacial implants, ID tags and biosensors
Reference:
Chetty, AS, Seynberg, TJ, Moolman, FS et al. 2006. Surface coated polyurethane with improved bioactivity and cytocompatability. CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 26-27 February 2006, pp1
Chetty, A., Seynberg, T., Moolman, F., Nilen, R., Joubert, A., & Richter, P. (2006). Surface coated polyurethane with improved bioactivity and cytocompatability. http://hdl.handle.net/10204/2677
Chetty, AS, TJ Seynberg, FS Moolman, RWN Nilen, AM Joubert, and PW Richter. "Surface coated polyurethane with improved bioactivity and cytocompatability." (2006): http://hdl.handle.net/10204/2677
Chetty A, Seynberg T, Moolman F, Nilen R, Joubert A, Richter P, Surface coated polyurethane with improved bioactivity and cytocompatability; 2006. http://hdl.handle.net/10204/2677 .
