Alpha-Arylation of inethanesulfonamides using palladium catalysis is described. For example, treatment of N-benzyl-Nmethylmethanesulfonamide with catalytic Pd (OAc) (2) in the presence of sodium tert-butoxide, triphenylphosphine and toluene afforded N-benzyl-N-methylphenylinethanesulfonamide in 66% yield.
Reference:
Zeevaart, JG, Parkinson, CJ and De Koning, CB. 2005. Palladium-catalysed arylation of sulfonamide stabilised enolates. Tetrahedron Letters, vol. 46(10), pp 1597-1599
Zeevaart, J., Parkinson, C., & De Koning, C. (2005). Palladium-catalysed arylation of sulfonamide stabilised enolates. http://hdl.handle.net/10204/1503
Zeevaart, JG, CJ Parkinson, and CB De Koning "Palladium-catalysed arylation of sulfonamide stabilised enolates." (2005) http://hdl.handle.net/10204/1503
Zeevaart J, Parkinson C, De Koning C. Palladium-catalysed arylation of sulfonamide stabilised enolates. 2005; http://hdl.handle.net/10204/1503.
