Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution
Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution
It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.
Reference:
Mandiwana, V., Kalombo, L., Hayeshi, R., Zeevaart, J. & Ebenhan, T. 2021. Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. Molecules, 26(9). http://hdl.handle.net/10204/12014
Mandiwana, V., Kalombo, L., Hayeshi, R., Zeevaart, J., & Ebenhan, T. (2021). Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. Molecules, 26(9), http://hdl.handle.net/10204/12014
Mandiwana, Vusani, Lonji Kalombo, R Hayeshi, JR Zeevaart, and T Ebenhan "Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution." Molecules, 26(9) (2021) http://hdl.handle.net/10204/12014
Mandiwana V, Kalombo L, Hayeshi R, Zeevaart J, Ebenhan T. Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. Molecules, 26(9). 2021; http://hdl.handle.net/10204/12014.
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