Author:Dye, C; Zhao, FZ; Scheele, S; Williams, BDate:Jun 2000Tuberculosis (TB) is still amongst the most important causes of human morbidity and mortality killing approximately two million people each year. Standard short-course chemotherapy (SSCC) can rapidly control illness and dramatically reduce ...Read more
Author:Van Reenen, Tobias H; Salie, F; Jensen, P; Nardell, E; Grobler, Jan-HendrikDate:Dec 2013The results of the recent study into the effectiveness of portable air cleaners (PACs), as an infection control measure against TB, delivered unexpectedly low results. That finding initiated a further study to understand the contribution of ...Read more
Author:Molemans, M; Van Leth, F; McKelly, David H; Wood, R; Hermans, SDate:Nov 2022Background: Individuals with a history of tuberculosis (TB) disease are at higher risk of developing a subsequent episode than those without. Considering the role of social and environmental factors in tuberculosis, we assessed neighbourhood-level ...Read more
Author:Bvumbi, Mpelegeng V; Van der Westhuyzen, Christiaan W; Mmutlane, EM; Ngwane, ADate:Jul 2021A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ...Read more
Author:Bvumbi, Mpelegeng V; Van der Westhuyzen, Christiaan W; Mmutlane, EM; Ngwane, ADate:Jul 2021A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ...Read more
Author:Rotherham, LS; Maserumule, C; Dheda, K; Theron, J; Khati, MDate:Oct 2012Despite the enormous global burden of tuberculosis (TB), conventional approaches to diagnosis continue to rely on tests that have major drawbacks. The improvement of TB diagnostics relies, not only on good biomarkers, but also upon accurate ...Read more