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Browsing Research Publications/Outputs by Impact Area "Synthetic Nanobiotech Biomachs"

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Advances in CRISPR-Cas9 for the Baculovirus Vector System: A systematic review

Author: Sari-Ak, D ; Alomari, O ; Shomali, RA ; Lim, J ; Thimiri Govindaraj, Deepak B Date: Dec 2022 The baculovirus expression vector systems (BEVS) have been widely used for the recombinant production of proteins in insect cells and with high insert capacity. However, baculovirus does not replicate in mammalian cells; thus, the BacMam ... Read more
Application of drug repurposing-based precision medicine platform for leukaemia patient treatment

Author: Kenmogne, Vanelle L ; Nweke, EE ; Takundwa, Mutsa M ; Fru, PN ; Thimiri Govindaraj, Deepak B Date: Oct 2022 Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a personalised treatment plan. It has helped to better stratify patients based on their molecular ... Read more
Aptamer-Based Tumor-Targeted Diagnosis and Drug Delivery

Author: Woldekidan, Haregewoin B ; Woldesemayat, AA ; Adam, G ; Tafesse, Mesfin ; Thimiri Govindaraj, Deepak B Date: Jul 2022 Early cancer identification is crucial for providing patients with safe and timely therapy. Highly dependable and adaptive technologies will be required to detect the presence of biological markers for cancer at very low levels in the early ... Read more
Bioinformatics tools for gene and genome annotation analysis of microbes for synthetic biology and cancer biology applications

Author: Nweke, EE ; Suleman, Essa ; Du Plessis, M ; Thimiri Govindaraj, Deepak B Date: Aug 2021 In this book chapter, we focus on application of genome annotation and analysis of microbes for synthetic biology and cancer biology research. We particularly emphasised on application of microbial genomics in synthetic biology and cancer ... Read more
CSIR Synthetic Biology and Precision Medicine Centre Bio-foundry Program

Author: Thimiri Govindaraj, Deepak B Date: Jan 2022 Global bio-foundry Alliance (GBA) has been established between countries including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 research institutions. Global bio-foundry Alliance plays the key role in the ... Read more
CSIR Synthetic Biology and Precision Medicine Centre Biofoundry Program: Development for first of its kind Biofoundry lab in Africa

Author: Thimiri Govindaraj, Deepak B Date: Mar 2023 Background: Global bio-foundry Alliance (GBA) has been established between countries including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 research institutions. Global bio-foundry Alliance plays the key ... Read more
CSIR technology platform for cancer precision medicine

Author: Thimiri Govindaraj, Deepak B ; Nxumalo, Precious Z Date: Feb 2021 Dr. Deepak Balaji Thimiri Govindaraj has been selected for an e-Poster presentation at the 2nd ESH Translational Research Conference on Chronic Lymphocytic Leukaemia. The Conference is proposing a programme of leading-edge basic and clinical ... Read more
Development of insect cell line using CRISPR technology

Author: Nweke, EE ; Thimiri Govindaraj, Deepak B Date: Feb 2021 In this chapter, we delineated the methods of CRISPR technology that has been used for the development of engineered insect cell line. We elaborated on how CRISPR/Cas9 genome editing in Drosophila melanogaster, Bombyx mori, Spodoptera frugiperda ... Read more
Drug sensitivity and drug repurposing platform for cancer precision medicine

Author: Nweke, EE ; Thimiri Govindaraj, Deepak B Date: Feb 2021 One of the critical Global challenges in achieving the UN Sustainable Development Goals 3 Good Health and Well Being is optimizing drug discovery and translational research for unmet medical need in both communicable and non-communicable ... Read more
Establishment of ex vivo drug sensitivity screening platform for leukaemia and multiple myeloma using a South African patient cohort

Author: Kenmogne, VL ; Takalani, AMT ; Nweke, EE ; Takundwa, Mutsa M ; Fabian, June ; Maher, Heather ; Du Toit, Justin ; Philip-Cherian, V ; Fru, PF ; Govindaraj, DBT Date: Oct 2023 Our objective is to develop a functional precision medicine platform designed to directly identify tailored drug regimens that target individual patient cancer cells and give benefit to the same donors by supporting clinical decision-making. ... Read more
Establishment of ex vivo drug sensitivity screening platform for leukaemia and multiple myeloma using a South African patient cohort

Author: Kenmogne, VL ; Takalani, AMT ; Nweke, EE ; Takundwa, Mutsa M ; Fabian, June ; Maher, Heather ; Du Toit, Justin ; Philip-Cherian, V ; Fru, PF ; Govindaraj, DBT Date: Oct 2023 Our objective is to develop a functional precision medicine platform designed to directly identify tailored drug regimens that target individual patient cancer cells and give benefit to the same donors by supporting clinical decision-making. ... Read more
Establishment of synthetic biology innovation and biofoundry lab in South Africa

Author: Thimiri Govindaraj, Deepak B Date: Sep 2023 Background: The Global Biofoundry Alliance (GBA) has been established between countries including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 research institutions. GBA plays a key role in the synthetic ... Read more
Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically

Author: Giliberto, M ; Thimiri Govindaraj, Deepak B ; Cremaschi, A ; Skånland, SS ; Gade, A ; Tjønnfjord, GE ; Schjesvold, F ; Munthe, LA ; Taskén, K Date: Mar 2022 The management of multiple myeloma (MM) is challenging: An assortment of available drug combinations adds complexity to treatment selection, and treatment resistance frequently develops. Given the heterogeneous nature of MM, personalized ... Read more
Magnetic nanoparticles: Role in next generation nanomedicine

Author: Latha, S ; Selvamani, P ; Palanisamy, SB ; Thimiri Govindaraj, Deepak B ; Thangavelu, P Date: Nov 2021 The magnetic nanoparticles are said to be a class of nanoparticles or nanomaterials that can be manipulated by the help of externally applied magnetic field. These magnetic nanoparticles constitute materials such as nickel, cobalt, iron, and ... Read more
Micro- and nanofluidics for high throughput drug screening

Author: Mathekga, BSP ; Nxumalo, Precious Z ; Thimiri Govindaraj, Deepak B Date: Jan 2022 In this book chapter, we elaborate on the state-of-the-art technology developments in high throughput screening, microfluidics and nanofluidics. This book chapter further elaborated on the application of microfluidics and nanofluidics for ... Read more
Patents and technology transfer in CRISPR technology

Author: Grobler, Lichelle R ; Suleman, Essa ; Thimiri Govindaraj, Deepak B Date: Feb 2021 CRISPR technology has revolutionized biological research in the last decade and many academic institutions and companies have patented CRISPR systems and applications. Several patents have been filed for various applications of CRISPR in ... Read more
Patents, ethics, biosafety and regulation using CRISPR technology

Author: Nxumalo, Precious Z ; Takundwa, MM ; Thimiri Govindaraj, Deepak B Date: Feb 2021 In this review chapter, we provide full comprehensive analysis on the patent, ethics and biosafety regulation with respect to the application of CRISPR technology in mammalian systems. We focused on recent development in CRISPR technology and ... Read more
Polyelectrolyte multifaceted magnetic microcapsules for magnetic drug targeting at rheumatoid arthritic joints

Author: Latha, S ; Palanisamy, S ; Chakrapani, P ; Harinia, R ; Babu, PS ; Thimiri Govindaraj, Deepak B Date: Mar 2021 Background: Drug delivery is a science that requires the development of tailored systems that can deliver defi nedquantities of a therapeutic payload at a specifi c target site, at a controlled release rate, with or without a specifi c ... Read more
Precision medicine using drug repurposing platform - the way forward in applying novel drug combinations for Ovarian Cancer treatment

Author: Batohi, Nikayla ; Dreyer, G ; Thimiri Govindaraj, Deepak B Date: Jan 2023 More than half of the women diagnosed with ovarian cancer ultimately succumb to death after 5 years of diagnosis. Standard platinum-based chemotherapy often results in patient relapse; thus, new therapeutic strategies are required. We aim to ... Read more
Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method

Author: Latha, S ; Selvamani, P ; Suganya, G ; Thimiri Govindaraj, Deepak B ; Pal, TK Date: Jun 2021 Magnetic microspheres incorporated with pantoprazole sodium—a proton pump inhibitor—were formulated by using two different polymers such as ethyl cellulose and Eudragit RS-100. The magnetic microspheres were prepared by emulsion solvent ... Read more

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