Author:Van der Westhuyzen, Christiaan W; Haynes, J; Panayides, Jenny-Lee; Wiid, I; Parkinson, CDate:2020Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like ...Read more
Author:Neyt, Nicole C; Van der Westhuizen, Johan C; Panayides, Jenny-Lee; Riley, DLDate:Mar 2022Ozonolysis is an attractive, efficient, and green means of introducing oxygen containing functionalities using only oxygen and electricity. Unfortunately, safety issues associated with the accumulation of dissolved ozone and potentially ...Read more
Author:Van van der Westhuizen, Johan C; Stander, A; Riley, DL; Panayides, Jenny-LeeDate:Mar 2022Alzheimer's disease is the most common neurodegenerative disease and currently poses a significant socioeconomic problem. This study describes the uses of computer-aided drug discovery techniques to identify novel inhibitors of acetylcholinesterase, ...Read more
Author:Wang, S; Panayides, Jenny-Lee; Riley, D; Tighe, CJ; Hii, KKDate:Sep 2021The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole ...Read more
Author:Bvumbi, Mpelegeng V; Van der Westhuyzen, Christiaan W; Mmutlane, EM; Ngwane, ADate:Jul 2021A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ...Read more
Author:Bvumbi, Mpelegeng V; Van der Westhuyzen, Christiaan W; Mmutlane, EM; Ngwane, ADate:Jul 2021A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ...Read more
Author:Van Wyk, LT; Neyt, Nicole C; Jugmohan, Jaimee; Panayides, Jenny-Lee; Riley, DLDate:Jan 2024Globally, major depressive disorders are a leading cause of disconsolateness affecting more than 300 million individuals. Bupropion is a unique dopamine-norepinephrine reuptake inhibitor (DNRI) commonly utilized in the treatment of depression, ...Read more