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Browsing by Impact Area "Human Molecular Diagnostics"

Now showing items 1-12 of 12

AI and precision oncology in clinical cancer genomics: From prevention to targeted cancer therapies-an outcomes based patient care

Author: Zodwa, Dlamini, Z ; Skepu, Amanda ; Kim, N ; Mkhabele, M ; Khanyile, R ; Molefi, T ; Mbatha, S ; Setlai, B ; Mulaudzi, T ; Mabongo, M Date: May 2022 Precision medicine is the personalization of medicine to suit a specific group of people or even an individual patient, based on genetic or molecular profiling. This can be done using genomic, transcriptomic, epigenomic or proteomic information. ... Read more
Boar seminal plasma proteomic profiling for biomarker discovery

Author: Mokwena, Pateswana W ; Stoychev, Stoyan H ; Buthelezi, Sindisiwe G ; Naicker, Previn ; Ramukhithi, FV ; Lehloenya, KC Date: Dec 2022 As an important technology in the swine industry, artificial insemination is of great significance in the preservation of elite breeds and the improvement of the utilisation rate of elite breeds, which makes the quality of preserved pig semen ... Read more
Candida parapsilosis cell wall proteome characterization and effectiveness against hematogenously disseminated candidiasis in a murine model

Author: Gong, X ; Srivastava, V ; Naicker, Previn ; Khan, A ; Ahmad, A Date: Mar 2023 Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ... Read more
Candida parapsilosis cell wall proteome characterization and effectiveness against hematogenously disseminated candidiasis in a murine model

Author: Gong, X ; Srivastava, V ; Naicker, Previn ; Khan, A ; Ahmad, A Date: Mar 2023 Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ... Read more
Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics

Author: Tumba, NL ; Naicker, Previn ; Stoychev, Stoyan H ; Killick, MA ; Owen, GR ; Papathanasopoulos, MA Date: Jul 2022 The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant Env bound to CD4 has been explored for its potential as an HIV vaccine immunogen as ... Read more
A look at emerging therapeutic targets for gallbladder cancer: A multi-omics approach

Author: Baichan, P ; Naicker, Previn ; Devar, J ; Smith, M ; Nweke, EE Date: Jan 2023 Gallbladder cancer (GBC) is the most frequent biliary tract cancer (including cancers of the intra- and extrahepatic biliary tree). Like many biliary tract carcinomas, GBC is identified by late diagnosis, poor prognosis, and ineffective ... Read more
Protective immunity of plant-produced African horse sickness virus serotype 5 chimaeric virus-like particles (VLPs) and viral protein 2 (VP2) vaccines in IFNAR-/- mice

Author: O'Kennedy, Maretha M ; Coetzee, P ; Koekemoer, O ; Du Plessis, L ; Lourens, CW ; Kwezi, Lusisizwe ; Du Preez, Ilse ; Mamputha, Sipho ; Rutkowska, Daria A ; Lemmer, Yolandy Date: Aug 2022 Next generation vaccines have the capability to contribute to and revolutionise the veterinary vaccine industry. African horse sickness (AHS) is caused by an arbovirus infection and is characterised by respiratory distress and/or cardiovascular ... Read more
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

Author: Baichan, P ; Naicker, Previn ; Augustine, TN ; Smith, M ; Candy, G ; Devar, J ; Nweke, EE Date: Mar 2023 Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specifc and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little ... Read more
Protocol for high-throughput semi-automated label-free- or TMT-based phosphoproteome profiling

Author: Koenig, C ; Martinez-Val, A ; Naicker, Previn ; Stoychev, S ; Jordaan, J ; Olsen, JV Date: Sep 2023 Tandem mass tags data-dependent acquisition (TMT-DDA) as well as data-independent acquisition-based label-free quantification (LFQ-DIA) have become the leading workflows to achieve deep proteome and phosphoproteome profiles. We present a ... Read more
Synthesis and characterisation of quantum dots coupled to mycolic acids as a water-soluble fluorescent probe for potential lateral flow detection of antibodies and diagnosis of tuberculosis

Author: Kabwe, KP ; Nsibande, SA ; Lemmer, Yolandy ; Pilcher, LA ; Forbes, PBC Date: Nov 2021 This work explores the potential use of cadmium-based quantum dots (QDs) coupled to mycolic acids (MAs) as a fluorescent probe to detect anti-MA antibodies which are biomarkers for tuberculosis (TB). The use of free MAs as antigens for the ... Read more
Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Author: Singh, Advaita A ; Pillay, Priyen ; Naicker, Previn ; Alexandre, Kabamba B ; Malatji, Kanyane ; Mach, L ; Steinkellner, H ; Vorster, J ; Chikwamba, Rachel K ; Tsekoa, Tsepo L Date: Aug 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases. This includes the induction of the expression of ... Read more
Urine-HILIC: Automated sample preparation for bottom-up urinary proteome profiling in clinical proteomics

Author: Govender, Ireshyn S ; Mokoena, Rethabile ; Stoychev, Stoyan ; Naicker, Previn Date: Sep 2023 Urine provides a diverse source of information related to a patient’s health status and is ideal for clinical proteomics due to its ease of collection. To date, most methods for the preparation of urine samples lack the throughput required ... Read more

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Browsing by Impact Area "Human Molecular Diagnostics"

Browsing by Impact Area "Human Molecular Diagnostics"

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