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Browsing by Impact Area "BT: Technology Demonstration"

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Development of a multiplex HIV/TB diagnostic assay based on the microarray technology

Author: Malatji, Kanyane ; Singh, Advaita A ; Thobakgale, C ; Alexandre, Kabamba Date: Sep 2023 Currently there are diagnostic tests available for human immunodeficiency virus (HIV) and tuberculosis (TB); however, they are still diagnosed separately, which can delay treatment in cases of co-infection. Here we report on a multiplex ... Read more
Engineering approaches in plant molecular farming for global health

Author: Singh, Advaita A ; Pillay, Priyen ; Tsekoa, Tsepo L Date: Nov 2021 Since the demonstration of the first plant-produced proteins of medical interest, there has been significant growth and interest in the field of plant molecular farming, with plants now being considered a viable production platform for vaccines. ... Read more
Gas chromatographic profiling of the biocatalytic conversion of sclareol to ambradiol by Hyphozyma roseoniger

Author: Ncube, EN ; Mathiba, Kgama ; Steenkamp, Lucia H ; Dubery, IA Date: Oct 2021 Hyphozyma roseoniger is a filamentous yeast used for its biocatalytic ability to convert sclareol, a plant diterpenoid to ambradiol, an intermediate to ambrafuran, which is a sought-after fixative in the perfume industry. Metabolite profiling ... Read more
A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration

Author: Singh, Advaita A ; Pillay, Priyen ; Kwezi, Lusisizwe ; Tsekoa, Tsepo L Date: Dec 2021 Despite a reduction in global HIV prevalence the development of a pipeline of new therapeutics or pre-exposure prophylaxis to control the HIV/AIDS epidemic are of high priority. Antibody-based therapies offer several advantages and have been ... Read more
Protective immunity of plant-produced African horse sickness virus serotype 5 chimaeric virus-like particles (VLPs) and viral protein 2 (VP2) vaccines in IFNAR-/- mice

Author: O'Kennedy, Maretha M ; Coetzee, P ; Koekemoer, O ; Du Plessis, L ; Lourens, CW ; Kwezi, Lusisizwe ; Du Preez, Ilse ; Mamputha, Sipho ; Rutkowska, Daria A ; Lemmer, Yolandy Date: Aug 2022 Next generation vaccines have the capability to contribute to and revolutionise the veterinary vaccine industry. African horse sickness (AHS) is caused by an arbovirus infection and is characterised by respiratory distress and/or cardiovascular ... Read more
Recombinant expression, purification and PEGylation of DNA Ligases

Author: Zuma, LK ; Gasa, NL ; Mazibuko, X ; Simelane, BC ; Pillay, Priyen ; Kwezi, Lusisizwe ; Tsekoa, Tsepo L ; Pooe, OJ Date: Apr 2022 Background: Reagent proteins such as DNA ligases play a central role in the global reagents market. DNA ligases are routinely used and are vital in academic and science research environments. Their major functions include sealing nicks by ... Read more
Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Author: Singh, Advaita A ; Pillay, Priyen ; Naicker, Previn ; Alexandre, Kabamba B ; Malatji, Kanyane ; Mach, L ; Steinkellner, H ; Vorster, J ; Chikwamba, Rachel K ; Tsekoa, Tsepo L Date: Aug 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases. This includes the induction of the expression of ... Read more

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Browsing by Impact Area "BT: Technology Demonstration"

Browsing by Impact Area "BT: Technology Demonstration"

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