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Browsing by Author "Naicker, Previn"

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Boar seminal plasma proteomic profiling for biomarker discovery

Author: Mokwena, Pateswana W ; Stoychev, Stoyan H ; Buthelezi, Sindisiwe G ; Naicker, Previn ; Ramukhithi, FV ; Lehloenya, KC Date: Dec 2022 As an important technology in the swine industry, artificial insemination is of great significance in the preservation of elite breeds and the improvement of the utilisation rate of elite breeds, which makes the quality of preserved pig semen ... Read more
Candida parapsilosis cell wall proteome characterization and effectiveness against hematogenously disseminated candidiasis in a murine model

Author: Gong, X ; Srivastava, V ; Naicker, Previn ; Khan, A ; Ahmad, A Date: Mar 2023 Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ... Read more
Candida parapsilosis cell wall proteome characterization and effectiveness against hematogenously disseminated candidiasis in a murine model

Author: Gong, X ; Srivastava, V ; Naicker, Previn ; Khan, A ; Ahmad, A Date: Mar 2023 Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ... Read more
Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics

Author: Tumba, NL ; Naicker, Previn ; Stoychev, Stoyan H ; Killick, MA ; Owen, GR ; Papathanasopoulos, MA Date: Jul 2022 The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant Env bound to CD4 has been explored for its potential as an HIV vaccine immunogen as ... Read more
The forkhead domain hinge-loop plays a pivotal role in DNA binding and transcriptional activity of FOXP2

Author: Morris, G ; Stoychev, Stoyan H ; Naicker, Previn ; Dirr, HW ; Fanucchi, Stephanie Date: Jul 2018 Forkhead box (FOX) proteins are a ubiquitously expressed family of transcription factors that regulate the development and differentiation of a wide range of tissues in animals. The FOXP subfamily members are the only known FOX proteins capable ... Read more
A look at emerging therapeutic targets for gallbladder cancer: A multi-omics approach

Author: Baichan, P ; Naicker, Previn ; Devar, J ; Smith, M ; Nweke, EE Date: Jan 2023 Gallbladder cancer (GBC) is the most frequent biliary tract cancer (including cancers of the intra- and extrahepatic biliary tree). Like many biliary tract carcinomas, GBC is identified by late diagnosis, poor prognosis, and ineffective ... Read more
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

Author: Baichan, P ; Naicker, Previn ; Augustine, TN ; Smith, M ; Candy, G ; Devar, J ; Nweke, EE Date: Mar 2023 Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specifc and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little ... Read more
Protocol for high-throughput semi-automated label-free- or TMT-based phosphoproteome profiling

Author: Koenig, C ; Martinez-Val, A ; Naicker, Previn ; Stoychev, S ; Jordaan, J ; Olsen, JV Date: Sep 2023 Tandem mass tags data-dependent acquisition (TMT-DDA) as well as data-independent acquisition-based label-free quantification (LFQ-DIA) have become the leading workflows to achieve deep proteome and phosphoproteome profiles. We present a ... Read more
SWATH-MS based proteomic profiling of Pancreatic Ductal Adenocarcinoma tumours reveals the interplay between the extracellular matrix and related intracellular pathways

Author: Nweke, EE ; Naicker, Previn ; Aaron, S ; Stoychev, Stoyan J ; Tabb, DL ; Jones, OJ ; Smith, MD ; Candy, GP Date: Jun 2020 Pancreatic cancer accounts for 2.8% of new cancer cases worldwide and is projected to become by 2030 the second leading cause of cancer-related deaths. Patients of African ancestry appear to be at an increased risk for pancreatic ductal ... Read more
Targeting gallbladder cancer: a pathway based perspective

Author: Baichan, P ; Naicker, Previn ; Devar, JWS ; Smith, M ; Candy, GP ; Nweke, E Date: Feb 2020 Gallbladder cancer (GBC) has a poor prognosis with a 5-year survival rate suggesting the need for more effective treatment strategies. Studying the cross-talk of several pathways involved in crucial cellular and biological processes such as ... Read more c b
Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Author: Singh, Advaita A ; Pillay, Priyen ; Naicker, Previn ; Alexandre, Kabamba B ; Malatji, Kanyane ; Mach, L ; Steinkellner, H ; Vorster, J ; Chikwamba, Rachel K ; Tsekoa, Tsepo L Date: Aug 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases. This includes the induction of the expression of ... Read more
Urine-HILIC: Automated sample preparation for bottom-up urinary proteome profiling in clinical proteomics

Author: Govender, Ireshyn S ; Mokoena, Rethabile ; Stoychev, Stoyan ; Naicker, Previn Date: Sep 2023 Urine provides a diverse source of information related to a patient’s health status and is ideal for clinical proteomics due to its ease of collection. To date, most methods for the preparation of urine samples lack the throughput required ... Read more
Zirconium(IV)-IMAC for phosphopeptide enrichment in phosphoproteomics

Author: Diez, IA ; Govender, Ireshyn S ; Naicker, Previn ; Stoychev, Stoyan H ; Jordaan, J ; Jensen, ON Date: Apr 2020 Phosphopeptide enrichment is an essential step in large-scale, quantitative phosphoproteomics studies by mass spectrometry. Several phosphopeptide affinity enrichment techniques exist, such as Immobilized Metal ion Affinity Chromatography ... Read more

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Browsing by Author "Naicker, Previn"

Browsing by Author "Naicker, Previn"

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