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Browsing by Author "Maphanga, Charles P"

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Detection of mycobacterium tuberculosis using gold nanoparticles conjugated to TB antibodies

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2021 In recent years, conjugated nanoparticles have gained significant applications in diagnostics, particularly gold nanoparticles (AuNPs). When functionalized with antibodies, AuNPs can selectively interact with cells and biomolecules. The ... Read more
Development of collinear transmission plasmonic biosensor for detection of HIV-1

Author: Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maphanga, Charles P ; Malabi, Rudzani ; Mthunzi-Kufa, Patience Date: Feb 2020 Surface Plasmon Resonance (SPR) which is widely used to study interactions between different types of biomolecules, has emerged as a technique of choice for rapid and quantitative analyses. However, there are still some challenges on the use ... Read more
Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles

Author: Oluwole, DA ; Manoto, Sello L ; Malabi, Rudzani ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience ; Nyokong, T Date: Mar 2018 We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical ... Read more
Label-free detection of mutations in the HIV genome using a surface plasmon resonance biosensor

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Thobakgale, Setumo L ; Mthunzi-Kufa, Patience Date: Mar 2021 Surface plasmon resonance (SPR) biosensors are optical materials that measure changes in the refractive index as they monitor non-covalent molecular interactions in real time. These utilise a label free analytical approach, which does not ... Read more
Near infrared femtosecond laser-induced bacterial inactivation

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Osualale, O ; Mthunzi-Kufa, Patience Date: Mar 2019 The use of light to inactivate microbes as an alternative method to the traditional methods of controlling microorganisms continues to draw the attention of researchers. Traditional methods of sterilization and/or pasteurization using chemicals ... Read more
Optical biosensing of mycobacterium tuberculosis for point-of-care diagnosis

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Hlekelele, Lerato ; Mthunzi-Kufa, Patience Date: Feb 2020 An optical biosensor is a compact analytical device formed by a bio-recognition sensing element integrated to an optical transducer system which translates a signal into a readable outcome that is measured by the detector. The target analyte ... Read more
Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells

Author: Manoto, Sello L ; Oluwole, DO ; Malabi, Rudzani ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Nyokong, T ; Mthunzi-Kufa, Patience Date: Feb 2017 Photodynamic therapy (PDT) is a minimally invasive therapeutic modality for the treatment of neoplastic and non-neoplastic diseases. In PDT of cancer, irradiation with light of a specific wavelength leads to activation of a photosensitizer, ... Read more
Pros and cons of characterising an optical translocation setup

Author: Maphanga, Charles P ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Feb 2017 The delivery of genetic material and drugs into mammalian cells using femtosecond (fs) laser pulses is escalating rapidly. This novel light based technique achieved through a precise focusing of a laser beam on the plasma membrane is called ... Read more
Raman spectroscopy and gold thin film for biosensing and detection

Author: Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maphanga, Charles P ; Malabi, Rudzani ; Thobakgale, Setumo L ; Lugongolo, Masixole Y ; Mthunzi-Kufa, Patience Date: Feb 2020 Raman spectroscopy is commonly used for sample characterization in biology because vibrational information is very specific to the chemical bonds in molecules. This makes it an attractive approach for identification of biological materials ... Read more
Surface plasmon resonance (SPR) based biosensor for mycobacterium tuberculosis diagnosis

Author: Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Mar 2021 Recently, various nanomaterials have been used to develop nanotechnology-based rapid diagnostic tests. Due to their unique optical properties, gold nanoparticles (AuNPs) have been employed to design and develop modern biosensors for the rapid ... Read more
Targeted femtosecond laser driven drug delivery within HIV-1 infected cells: In-vitro studies [conference paper]

Author: Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maaza, Malik ; Mthunzi-Kufa, Patience Date: Jan 2017 Human immunodeficiency virus (HIV-1) infection still remains one amongst the world’s most challenging infections since its discovery. Antiretroviral therapy is the recommended treatment of choice for HIV-1 infection taken by patients orally. ... Read more
Therapeutic strategies to fight HIV-1 latency: progress and challenges

Author: Manoto, Sello L ; Thobakgale, Setumo L ; Malabi, Khorommbi P ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Oct 2017 The life-long persistence of human immunodeficiency virus type-1 (HIV-1) in latent reservoirs is a major hurdle in the eradication of HIV-1, even though highly active antiretroviral therapy (HAART) can be effective in reducing the plasma HIV-1 ... Read more

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Browsing by Author "Maphanga, Charles P"

Browsing by Author "Maphanga, Charles P"

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