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Browsing by Author "Kwezi, Lusisizwe"

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The brassinosteroid receptor BRI1 can generate cGMP enabling cGMP-dependent downstream signaling

Author: Wheeler, J ; Wong, A ; Marondedze, C ; Groen, AJ ; Kwezi, Lusisizwe Date: Jun 2017 The brassinosteroid receptor brassinosteroid insensitive 1 (BRI1) is a member of the leucine-rich repeat receptor-like kinase family. The intracellular kinase domain of BRI1 is an active kinase and also encapsulates a guanylate cyclase catalytic ... Read more
Enantioselective biocatalytic hydrolysis of ß-aminonitriles to ß-amino-amides using Rhodococcus rhodochrous ATCC BAA-870

Author: Chhiba, Varsha P ; Bode, M ; Mathiba, K ; Kwezi, Lusisizwe ; Brady, D Date: Apr 2012 A range of ß-aminonitriles (3-amino-3-phenylpropanenitrile and derivatives) were synthesised by reaction of various benzonitriles with acetonitrile and subsequent reduction of the resulting acrylonitrile products. These compounds were hydrolysed ... Read more
Intramolecular crosstalk between catalytic activities of receptor kinases

Author: Kwezi, Lusisizwe ; Wheeler, JI ; Marondedze, C ; Gehring, C ; Irving, HR Date: Feb 2018 Signal modulation is important for the growth and development of plants and this process is mediated by a number of factors including physiological growth regulators and their associated signal transduction pathways. Protein kinases play a ... Read more
Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1

Author: Muleya, V ; Marondedze, C ; Wheeler, JI ; Thomas, L ; Mok, YF ; Griffin, MD ; Manallack, DT ; Kwezi, Lusisizwe ; Lilley, KS ; Gehring, C ; Irving, HR Date: Oct 2016 Phytosulfokines (PSKs) are plant peptide hormones that co-regulate plant growth, differentiation and defense responses. PSKs signal through a plasma membrane localized leucine-rich repeat receptor-like kinase (phytosulfokine receptor 1, PSKR1) ... Read more
Plant-based production of highly potent anti-HIV antibodies with engineered posttranslational modifications

Author: Singh, Advaita Acarya ; Pooe, O ; Kwezi, Lusisizwe ; Lotter-Stark, T ; Stoychev, Stoyan H ; Alexandra, Kabamba B ; Gerber, Isak B ; Bhiman, JN ; Vorster, J ; Pauly, M ; Zeitlin, L ; Whaley, K ; Mach, L ; Steinkellner, H ; Morris, L ; Tsekoa, Tsepo L ; Chikwamba, Rachel K Date: Apr 2020 Broadly neutralising antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1), such as CAP256-VRC26 are being developed for HIV prevention and treatment. These Abs carry a unique but crucial post-translational modification (PTM), ... Read more
A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration

Author: Singh, Advaita A ; Pillay, Priyen ; Kwezi, Lusisizwe ; Tsekoa, Tsepo L Date: Dec 2021 Despite a reduction in global HIV prevalence the development of a pipeline of new therapeutics or pre-exposure prophylaxis to control the HIV/AIDS epidemic are of high priority. Antibody-based therapies offer several advantages and have been ... Read more
Protective immunity of plant-produced African horse sickness virus serotype 5 chimaeric virus-like particles (VLPs) and viral protein 2 (VP2) vaccines in IFNAR-/- mice

Author: O'Kennedy, Maretha M ; Coetzee, P ; Koekemoer, O ; Du Plessis, L ; Lourens, CW ; Kwezi, Lusisizwe ; Du Preez, Ilse ; Mamputha, Sipho ; Rutkowska, Daria A ; Lemmer, Yolandy Date: Aug 2022 Next generation vaccines have the capability to contribute to and revolutionise the veterinary vaccine industry. African horse sickness (AHS) is caused by an arbovirus infection and is characterised by respiratory distress and/or cardiovascular ... Read more
Recombinant expression, purification and PEGylation of DNA Ligases

Author: Zuma, LK ; Gasa, NL ; Mazibuko, X ; Simelane, BC ; Pillay, Priyen ; Kwezi, Lusisizwe ; Tsekoa, Tsepo L ; Pooe, OJ Date: Apr 2022 Background: Reagent proteins such as DNA ligases play a central role in the global reagents market. DNA ligases are routinely used and are vital in academic and science research environments. Their major functions include sealing nicks by ... Read more

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Browsing by Author "Kwezi, Lusisizwe"

Browsing by Author "Kwezi, Lusisizwe"

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All of ResearchSpace

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Legislation and compliance

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