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Browsing by Author "Jones, AT"

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Lipid containing nanodrug delivery system for the treatment of Tuberculosis

Author: Lemmer, Yolandy ; Semete, B ; Kalombo, Lonji ; Ramalapa, B ; Jones, AT ; Swai, HS ; Verschoor, JA Date: 01 Sep 2010 Challenges in treatment of Tuberculosis (TB) include non-specific localisation of the drugs which results in too low concentrations of the drugs reaching the target site of infection, thus leading to reduced effectiveness. To improve the ... Read more
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Author: Lemmer, Yolandy ; Kalombo, Lonji ; Pietersen, R-D ; Jones, AT ; Semete-Makokotlela, Boitumelo ; Van Wyngaardt, S ; Ramalapa, BE ; Stoltz, A ; Baker, B ; Verschoor, JA ; Swai, HS ; De Chastellier, C Date: Jun 2015 The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations ... Read more
Nanoencapsulation of Mycolic acids as a deliverable to macrophages

Author: Benadie, Y ; Semete, B ; Venter, L ; Kalombo, Lonji ; Driver, C ; Jones, AT ; Swai, H ; Verschoor, JA Date: Jun 2008 The cell wall envelope of Mycobacterium tuberculosis contains unique high molecular weight lipids. Of these, the most abundant are mycolic acids, an extended family of long 2-alkyl 3-hydroxyl fatty acids, typically 70-90 carbon atoms in length, ... Read more
Nanoencapsulation of mycolic acids as a deliverable to macrophages - 2nd CSIR Biennial Conference

Author: Benadie, Y ; Semete, B ; Venter, L ; Kalombo, Lonji ; Driver, C ; Jones, AT ; Swai, H ; Verschoor, JA Date: Nov 2008 The objective of this project was to explore the encapsulation of mycolic acids into vehicles other than liposomes for delivery into macrophages and addressing the challenges of low solubility. As vehicles nanoparticles (NP) have the advantage ... Read more
Targeted nanodrug delivery systems for the treatment of Tuberculosis

Author: Lemmer, Yolandy ; Semete, B ; Booysen, L ; Kalombo, Lonji ; Katata, L ; Jones, AT ; Alexander, C ; Khati, M ; Swai, HS ; Verschoor, JA Date: Jun 2010 South Africa currently has the highest incidence of TB per 100000 (358 per 100000) people in the world. In 2007 alone 112000 people died of TB in South Africa, of which 94 000 (72%) were co-infected with HIV. Although TB treatments exist, ... Read more

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Browsing by Author "Jones, AT"

Browsing by Author "Jones, AT"

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