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Browsing by Author "Green, IR"

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Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

Author: Panayides, Jenny-Lee ; Mathieu, V ; Banuls, LMY ; Apostolellis, H ; Dahan-Farkas, N ; Davids, H ; Harmse, L ; Rey, MEC ; Green, IR ; Pelly, SC ; Kiss, R ; Kornienko, A ; Van Otterlo, WAL Date: Jun 2016 Seventeen silyl- and trityl-modified (5'-O- and 3',5'-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a ... Read more
Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation

Author: Mabank, T ; Alexandre, Kabamba B ; Pelly, SC ; Green, IR ; Van Otterlo, WAL Date: Jul 2019 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds ... Read more

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Browsing by Author "Green, IR"

Browsing by Author "Green, IR"

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